Steroidogenic Acute Regulatory Protein Expression in the Central Nervous System
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چکیده
منابع مشابه
Steroidogenic Acute Regulatory Protein Expression in the Central Nervous System
Locally produced neurosteroids are proposed to have many functions in the central nervous system. The identification of the steroidogenic acute regulatory protein in steroid-producing neural cells provides a new tool to understand the sites, regulation, and importance of their synthesis.
متن کاملOxysterols regulate expression of the steroidogenic acute regulatory protein.
The steroidogenic acute regulatory (StAR) protein promotes intramitochondrial delivery of cholesterol to the cholesterol side-chain cleavage system, which catalyzes the first enzymatic step in all steroid synthesis. Intriguingly, substrate cholesterol derived from lipoprotein can upregulate StAR gene expression. Moreover, substrate oxysterols have been suggested to also play a role. To investig...
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Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...
متن کاملNeurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.
Institut Fédératif de Recherches Multidisciplinaires sur Les Peptides no. 23, Laboratoire de Neuroendocrinologie Cellulaire et Moléculaire, Institut National de la Santé et de la Recherche Médicale U 413, UA Centre National de la Recherche Scientifique, Université de Rouen, Mont-Saint-Aignan, France (A.G.M.-N., J.-L.D.-R., D.B., H.V.); and Centre de Recherches en Endocrinologie Moléculaire, Le ...
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Listeriosis is one of the CNS inflammatory diseases which is happened majority in the form of sporadic. Listeriosis is ingested with the food. Infection occurrence in an exposed person depends on the number of organisms ingested, the virulence of the organisms strain and the individual condition. It is known that Listeriosis has decisive importance as an infection which the cellular immunodefen...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2011
ISSN: 1664-2392
DOI: 10.3389/fendo.2011.00072